Review
Nature Reviews Molecular Cell Biology 3, 944-956 (December 2002) | doi:10.1038/nrm972
Immunoglobulin transport across polarized epithelial cells
Raul Rojas1 & Gerard Apodaca1 About the authors
Abstract
IgA, IgG and IgM are transported across epithelial cells in a receptor-mediated process known as transcytosis. In addition to neutralizing pathogens in the lumen of the gastrointestinal, respiratory and urogenital tracts, these antibody–receptor complexes are now known to mediate intracellular neutralization of pathogens and might also be important in immune activation and tolerance. Recent studies on the intracellular transport pathways of antibody–receptor complexes and antibody-stimulated receptor-mediated transcytosis are providing new insight into the nature and regulation of endocytic pathways.
- View At a Glance
Author affiliations
- Laboratory of Epithelial Cell Biology, Renal Electrolyte Division of the Departments of Medicine, Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
Correspondence to: Gerard Apodaca1 Email: gla6@pitt.edu
|
MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated REFERENCE NEWS AND VIEWS RESEARCH |
