Perspectives
Nature Reviews Molecular Cell Biology 3, 957-964 (December 2002) | doi:10.1038/nrm971
Opinion: How do microtubules guide migrating cells?
J. Victor Small1, Benjamin Geiger2, Irina Kaverina1 & Alexander Bershadsky2 About the authors
Abstract
Microtubules have long been implicated in the polarization of migrating cells, but how they carry out this role is unclear. Here, we propose that microtubules determine cell polarity by modulating the pattern of adhesions that a cell develops with the underlying matrix, through focal inhibitions of contractility.
Author affiliations
- J. Victor Small and Irina Kaverina are at the Institute of Molecular Biology, Austrian Academy of Sciences, Billrothstrasse 11, Salzburg 5020, Austria.
- Benjamin Geiger and Alexander Bershadsky are at the Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.
Correspondence to: J. Victor Small1 Email: jvsmallimb.oeaw.ac.at
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