Review
Nature Reviews Molecular Cell Biology 3, 731-741 (October 2002) | doi:10.1038/nrm929
The spindle checkpoint: structural insights into dynamic signalling
Andrea Musacchio1 & Kevin G. Hardwick2 About the authors
Abstract
Chromosome segregation is a complex and astonishingly accurate process whose inner working is beginning to be understood at the molecular level. The spindle checkpoint plays a key role in ensuring the fidelity of this process. It monitors the interactions between chromosomes and microtubules, and delays mitotic progression to allow extra time to correct defects. Here, we review and integrate findings on the dynamics of checkpoint proteins at kinetochores with structural information about signalling complexes.
- View At a Glance
Author affiliations
-
Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy.
Email: amusacch@ieo.it -
Wellcome Trust Centre for Cell Biology, ICMB, University of Edinburgh, King's Buildings, Mayfield Road, Edinburgh EH9 3JR, UK.
Email: Kevin.Hardwick@ed.ac.uk
|
MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated REFERENCE NEWS AND VIEWS RESEARCH |
