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Review
Nature Reviews Molecular Cell Biology 2, 433–443 (1 June 2001) | doi:10.1038/35073057
The junction-resolving enzymes
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Abstract
Junction-resolving enzymes are ubiquitous nucleases that are important for DNA repair and recombination and act on DNA molecules containing branch points, especially four-way junctions. They show a pronounced selectivity for the structure of the DNA substrate but, despite its importance, the structural selectivity is not well understood. This poses an intriguing challenge in molecular recognition on a relatively large scale.
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