Review
Nature Reviews Molecular Cell Biology 2, 457-466 (June 2001) | doi:10.1038/35073084
Living dangerously: how Helicobacter pylori survives in the human stomach
Cesare Montecucco1 & Rino Rappuoli1 About the authors
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Abstract
Helicobacter pylori was already present in the stomach of primitive humans as they left Africa and spread through the world. Today, it still chronically infects more than 50% of the human population, causing, in some cases, severe diseases such as peptic ulcers and stomach cancer. To succeed in these long-term associations, H. pylori has developed a unique set of virulence factors, which allow survival in a unique and hostile ecological niche — the human stomach.
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Author affiliations
- Centro CNR Biomembrane e Dipartimento di Scienze Biomediche, Università di Padova, Via G. Colombo 3, 35121 Padova, Italy and Centro di Ricerche IRIS, Chiron S.p.A., Via Fiorentina, 1, 53100 Siena, Italy. Email: cesare@civ.bio.unipd.it
