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Review
Nature Reviews Molecular Cell Biology 2, 294–307 (1 April 2001) | doi:10.1038/35067100
Cbl: many adaptations to regulate protein tyrosine kinases
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Abstract
Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes?
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