Review
Nature Reviews Molecular Cell Biology 2, 257-267 (April 2001) | doi:10.1038/35067005
Tie receptors: new modulators of angiogenic and lymphangiogenic responses
Nina Jones1, Kristiina Iljin2 About the authors, Daniel J. Dumont1 & Kari Alitalo2
Abstract
Angiogenesis is required for normal embryonic vascular development and aberrant angiogenesis contributes to several diseases, including cancer, diabetes and tissue ischaemia. What are the molecular mechanisms that regulate this important process? The Tie family of receptors and their ligands, the angiopoietins, are beginning to provide insight into how vessels make decisions such as whether to grow or regress — processes that are important not only during development but throughout an organism's life.
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Author affiliations
- Department of Medical Biophysics, University of Toronto, Sunnybrook and Women's College Health Sciences Centre, 2075 Bayview Avenue, S-227, Toronto, Ontario, Canada M4N 3M5.
- Molecular/Cancer Biology Laboratory, Ludwig Institute for Cancer Research, Biomedicum Institute, University of Helsinki, P.O. Box 21 (Haartmaninkatu 3), SF-00014 Helsinki, Finland.
Correspondence to: Kari Alitalo2 Email: Kari.Alitalo@Helsinki.FI
