Nature Reviews Molecular Cell Biology
Figure 2 FLASH ANIMATION
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Figure 2 | Antigen processing and presentation.
a | Most substrates that harbour MHC class I epitopes are conjugated
with a multi-ubiquitin chain, which targets it to the 26S proteasome for degradation80. b | Proteasomal protein substrate processing results in
the generation of peptides of 811 residues in length, which are
c | transported into the endoplasmic reticulum (ER) by the transporter
associated with antigen presentation (TAP) complex81, 82.
d | Within the ER, peptides bind to and stabilize the MHC class I heterodimers,
which comprise a heavy chain and a 2 microglobulin molecule. e
| Importantly, the assembly of MHC molecules is coordinated by molecular chaperones
such as BiP, calreticulin and ERp57; only fully assembled, peptide-loaded
MHC molecules are translocated, through the Golgi apparatus, to the cell surface83-85. f | By binding specifically to a given MHC allomorph
an MHC molecule encoded by a specific haplotype loaded with
a unique peptide, cytotoxic T cells with complementary T-cell receptors (TCRs)
are stimulated to proliferate and destroy the infected target cell.
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