Review
Nature Reviews Molecular Cell Biology 2, 138-145 (February 2001) | doi:10.1038/35052082
Filamins as integrators of cell mechanics and signalling
Thomas P. Stossel1, John Condeelis2, Lynn Cooley3, John H. Hartwig1, Angelika Noegel4, Michael Schleicher5 & Sandor S. Shapiro6 About the authors
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Abstract
Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions and are essential for fetal development and cell locomotion. Here, we describe the history, structure and function of this group of proteins.
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Author affiliations
- Brigham and Women's Hospital, Boston, Massachusetts, 02115 USA. Email: tstossel@rics.bwh.harvard.edu
- Albert Einstein College of Medicine, New York, New York 10461, USA.
- Yale Medical School, New Haven, Connecticut 06520, USA.
- University of Cologne, Cologne D-50931, Germany.
- Ludwig-Maximilians University, Munich D-80336, Germany.
- Jefferson Medical College, Philadelphia , Pennsylvania 19107, USA.
