Review
Nature Reviews Molecular Cell Biology 2, 749-759 (October 2001) | doi:10.1038/35096019
A decade of CDK5
Rani Dhavan1 & Li-Huei Tsai1 About the authors
Top of page
Abstract
Since it was identified a decade ago, cyclin-dependent kinase 5 (CDK5) has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes ? from adhesion and motility, to synaptic plasticity and drug addiction. Recent evidence indicates that deregulation of this kinase is involved in the pathology of neurodegenerative diseases.
- View At a Glance
Author affiliations
- Department of Pathology, Harvard Medical School, Howard Hughes Medical Institute, 200 Longwood Avenue, Boston, Massachusetts 02115, USA.
Correspondence to: Email: li-huei_tsai@hms.harvard.edu
