Review
Nature Reviews Molecular Cell Biology 2, 731-737 (October 2001) | doi:10.1038/35096061
The INK4a/ARF network in tumour suppression
Charles J. Sherr1 About the author
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Abstract
The retinoblastoma protein (RB) and p53 transcription factor are regulated by two distinct proteins that are encoded by the INK4a/ARF locus. Genes encoding these four tumour suppressors are disabled, either in whole or in part, in most human cancers. A complex signalling network that interconnects the activities of RB and p53 monitors oncogenic stimuli to provide a cell-autonomous mode of tumour surveillance.
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Author affiliations
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Department of Tumor Cell Biology, Howard Hughes Medical Institute, St Jude Children's Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA.
Email: sherr@stjude.org
