Figure 2 | Two directions for proteomics in protein interaction mapping.   In classical proteomics, the starting material is the organism of interest. Protein complexes are isolated and analysed, and complete genome sequences are used to identify complex components. In reverse proteomics, the starting point is the DNA sequence of the genome of an organism. First, the transcriptome (complete set of transcripts) and proteome (complete set of proteins) are predicted in silico and subsequently this information is used to generate reagents for their analysis.

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