Figure 1 | Protein interactions are crucial in many aspects of biological function.   a | Genetic interactions often correlate with physical interactions between the corresponding gene-products. b | Signal-transduction pathways can be tethered to a subcellular location by scaffolding proteins. c | Many enzyme–protein substrate interactions are surprisingly stable and can therefore be detected in protein interaction assays. d | Protein interactions form the basis for the function of large molecular machines.

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