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Epigenetics

Maternal TRIM28 for male embryos

Nature Reviews Molecular Cell Biology volume 18, pages 138–139 (2017)Cite this article

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TRIM28 mediates the establishment and maintenance of DNA methylation; when the Trim28 gene is deleted in oocytes, DNA methylation at imprinted genes is lost in pre-implantation embryos. The authors found that more than half of such maternal Trim28 null (Trim28matΔ/+) embryos were resorbed immediately after implantation. Implanting embryos exhibited varying degrees of morphological abnormality that are associated with apoptosis, including fragmented nuclei with active caspase 3.

maternal Trim28 alone is necessary and sufficient for Rbmy1a1 silencing in pre-implantation embryos

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References

  1. Sampath Kumar, A. et al. Loss of maternal Trim28 causes male-predominant early embryonic lethality. Genes Dev. 31, 12–17 (2017)

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  1. Eytan Zlotorynski
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Zlotorynski, E. Maternal TRIM28 for male embryos. Nat Rev Mol Cell Biol 18, 138–139 (2017). https://doi.org/10.1038/nrm.2017.13

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