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Cep135, Ana1 (Cep295) and Asterless (Cep152) are sequentially recruited to daughter centrioles to enable their maturation into duplication-competent mother centrioles.
M. Bishr Omary reminds us of the three articles that first uncovered a causative link between mutations in intermediate filaments (specifically, keratin 14) and human diseases.
The CRISPR–Cas9 system is a powerful, sequence-specific tool that was initially developed for gene and genome editing. The recent adoption of nuclease-deactivated Cas9 (dCas9) has enabled expansion of the use of the system to multiplexed and inducible transcription regulation, genome-wide screens and cell fate engineering.
Most eukaryotic centromeres are defined epigenetically and require nucleosomes containing the histone H3 variant centromere protein A (CENP-A). We are now gaining insight into the mechanisms that regulate CENP-A deposition and positioning to specify and propagate centromeres during cell division, and into the function of centromeres in recruiting kinetochores to connect chromosomes to spindle microtubules.
Recent studies inArabidopsis thalianahave identified interconnected signalling networks that regulate plant vascular development. These findings have increased our understanding of vascular development from early cell specification during embryogenesis to the latest stages of differentiation of the phloem and xylem.
In addition to its known roles in nonsense-mediated mRNA decay, recent findings show that the exon junction complex (EJC) participates in diverse mRNA maturation processes, including splicing, transport and translation. This multi-functionality is reflected by an increasing number of EJC-related disorders being discovered.
Catenins are typically considered to function at cell–cell junctions. However, it has recently become evident that multiple catenins can enter the nucleus and regulate gene expression. Thus, catenins might form complex networks, coupling membrane-associated signalling with transcriptional events.
