Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Berkovits and Mayr show that 3′ UTRs generated by alternative polyadenylation can recruit the RNA-binding protein HUR and its effector SET, which regulate the cellular localization of the translated proteins.
Apoptosis, autophagy and necroptosis are discussed in the context of molecular mechanisms of programmed cell death during development and tissue homeostasis. The signals that dying cells produce can in turn induce the apoptosis or proliferation of neighbouring cells.
Mitochondrial proteases can be classified into subgroups depending on their function and location. They are highly specific and modulate biochemical activities that are essential for mitochondrial function and integrity. Impaired or dysregulated function of mitoproteases is associated with ageing and longevity, as well as with pathological conditions and human hereditary diseases.
During the G1–S phase transition of the cell cycle, a variable subset of previously 'licensed' origins of replication is activated to initiate DNA synthesis. Insight is being gained into the mechanisms underlying which origins are activated and when; these mechanisms are associated with nuclear organization, cell differentiation and replication stress.
The mitochondrial respiratory chain comprises large multi-subunit protein complexes that generate ATP. The crystal structure of the entire bacterial complex I was recently solved, providing novel insights into its core architecture, as well as the electron transfer and proton translocation pathways and the coupling between them.