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Volume 16 Issue 6, June 2015

'Replication in space' by Vicky Summersby, inspired by the Review on p360.

Research Highlight

  • Guttman and colleagues discovered proteins that bind the lncRNAXistand mediate gene silencing during X-chromosome inactivation.

    • Eytan Zlotorynski
    Research Highlight

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  • Dishevelled recruits E3 ligases to WNT co-receptors to facilitate their degradation and the downregulation of WNT signalling.

    • Andrea Du Toit
    Research Highlight
  • Berkovits and Mayr show that 3′ UTRs generated by alternative polyadenylation can recruit the RNA-binding protein HUR and its effector SET, which regulate the cellular localization of the translated proteins.

    • Eytan Zlotorynski
    Research Highlight
  • Microtubule detyrosination guides CENP-E-dependent transport of pole-proximal chromosomes to the spindle equator during mitosis.

    • Kim Baumann
    Research Highlight
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In Brief

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Research Highlight

  • The basket nucleoproteins Nup1 and Nup60 contribute to nuclear pore complex formation by inducing membrane curvature.

    • Kirsty Minton
    Research Highlight
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Review Article

  • Mitochondrial proteases can be classified into subgroups depending on their function and location. They are highly specific and modulate biochemical activities that are essential for mitochondrial function and integrity. Impaired or dysregulated function of mitoproteases is associated with ageing and longevity, as well as with pathological conditions and human hereditary diseases.

    • Pedro M. Quirós
    • Thomas Langer
    • Carlos López-Otín
    Review Article
  • During the G1–S phase transition of the cell cycle, a variable subset of previously 'licensed' origins of replication is activated to initiate DNA synthesis. Insight is being gained into the mechanisms underlying which origins are activated and when; these mechanisms are associated with nuclear organization, cell differentiation and replication stress.

    • Michalis Fragkos
    • Olivier Ganier
    • Marcel Méchali
    Review Article
  • The mitochondrial respiratory chain comprises large multi-subunit protein complexes that generate ATP. The crystal structure of the entire bacterial complex I was recently solved, providing novel insights into its core architecture, as well as the electron transfer and proton translocation pathways and the coupling between them.

    • Leonid A. Sazanov
    Review Article
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