Nature Reviews Molecular Cell Biology 13, 616-630 (October 2012) | doi:10.1038/nrm3434

TGFβ signalling in context

Joan Massagué1  About the author


The basic elements of the transforming growth factor-β (TGFβ) pathway were revealed more than a decade ago. Since then, the concept of how the TGFβ signal travels from the membrane to the nucleus has been enriched with additional findings, and its multifunctional nature and medical relevance have relentlessly come to light. However, an old mystery has endured: how does the context determine the cellular response to TGFβ? Solving this question is key to understanding TGFβ biology and its many malfunctions. Recent progress is pointing at answers.

Author affiliations

  1. Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA. Box 116, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA.

Correspondence to: Joan Massagué1 Email:

Published online 20 September 2012