Table of contents


From the editors

p365 | doi:10.1038/nrm2706

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Research Highlights

Chromatin: CENP-A on target | PDF (153 KB)

p367 | doi:10.1038/nrm2704

Protein degradation: Tipping the balance | PDF (133 KB)

p368 | doi:10.1038/nrm2701

Cell migration: Talin heads off | PDF (237 KB)

p368 | doi:10.1038/nrm2702

Plant cell biology: New receptors for ABA | PDF (280 KB)

p368 | doi:10.1038/nrm2703

Protein degradation: Chain gang | PDF (162 KB)

p370 | doi:10.1038/nrm2691

Technology Watch

Hunting phosphoproteins | See the force | PDF (125 KB)

p370 | doi:10.1038/nrm2705

Post-translational modification: Examining the Fic domain | PDF (189 KB)

p371 | doi:10.1038/nrm2696

DNA repair: Time to switch | PDF (198 KB)

p371 | doi:10.1038/nrm2700

Prions: Prying into prions | PDF (164 KB)

p372 | doi:10.1038/nrm2692

Journal Club

Freedom versus constraint in protein function | PDF (138 KB)

p372 | doi:10.1038/nrm2697

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Reviews

Article series: Chromatin dynamics

Chromatin remodelling beyond transcription: the INO80 and SWR1 complexes

Ashby J Morrison & Xuetong Shen

p373 | doi:10.1038/nrm2693

ATP-dependent chromatin-remodelling complexes are well-known regulators of transcriptional processes. Interestingly, the INO80 and SWR1 complexes also participate in a range of pathways that are involved in genome maintenance, such as DNA repair, checkpoint regulation, DNA replication, chromosome segregation and telomere stabilization.

The ubiquitin–26S proteasome system at the nexus of plant biology

Richard D. Vierstra

p385 | doi:10.1038/nrm2688

The ubiquitin–26S proteasome system is one of the most pervasive pathways of intracellular protein regulation in plants. It controls hormone signalling, chromatin structure and transcription, tailoring morphogenesis, responses to environmental challenges, self-recognition and the battle between pathogens and their plant hosts.

Physiological functions of the HECT family of ubiquitin ligases

Daniela Rotin & Sharad Kumar

p398 | doi:10.1038/nrm2690

Ubiquitylation targets proteins for degradation or other cellular fates. The HECT enzymes are E3 ubiquitin ligases, which dictate the specificity of ubiquitylation. HECTs regulate trafficking of many receptors, channels, transporters and viral proteins. Their role in metazoans is becoming clearer from in vivo studies.

The second wave of synthetic biology: from modules to systems

Priscilla E. M. Purnick & Ron Weiss

p410 | doi:10.1038/nrm2698

Synthetic biology combines the investigative nature of biology with the constructive nature of engineering. A 'first wave' in the field has led to the creation of genetic devices and small modules that are constructed from these devices. Now, a 'second wave' is required to develop effective strategies for assembling devices and modules into intricate customizable larger scale systems.

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Perspectives

Opinion

It takes two to tango: regulation of G proteins by dimerization

Raphael Gasper, Simon Meyer, Katja Gotthardt, Minhajuddin Sirajuddin & Alfred Wittinghofer

p423 | doi:10.1038/nrm2689

Guanine nucleotide-binding (G) proteins are regulated by GTPase-activating proteins and guanine nucleotide-exchange factors. Another class of G proteins is emerging that are regulated by homodimerization. The authors propose that juxtaposition of the G domains of two monomers across the GTP-binding sites activates the biological function of these proteins and the GTPase reaction.

Opinion

RNA granules: post-transcriptional and epigenetic modulators of gene expression

Paul Anderson & Nancy Kedersha

p430 | doi:10.1038/nrm2694

Compositionally and functionally distinct RNA granules are found in the cytoplasm of somatic and germ cells. The components of most RNA granules are in a dynamic equilibrium, thereby allowing rapid shifts between the translation, storage and decay of RNAs.