Review
Nature Reviews Molecular Cell Biology 10, 276-286 (April 2009) | doi:10.1038/nrm2654
-Catenin hits chromatin: regulation of Wnt target gene activation
Christian Mosimann1,2, George Hausmann1 & Konrad Basler1 About the authors
Abstract
The canonical Wnt pathway has gathered much attention in recent years owing to its fundamental contribution to metazoan development, tissue homeostasis and human malignancies. Wnt target gene transcription is regulated by nuclear 
-catenin, and genetic assays have revealed various collaborating protein cofactors. Their daunting number and diverse nature, however, make it difficult to arrange an orderly picture of the nuclear Wnt transduction events. Yet, these findings emphasize that -catenin-mediated transcription affects chromatin. How does -catenin cope with chromatin regulation to turn on Wnt target genes?
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Author affiliations
- National Research Center "Frontiers in Genetics", Institut für Molekularbiologie, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
- Present address: Children's Hospital Boston, Division of Hematology/Oncology, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Correspondence to: Konrad Basler1 Email: konrad.basler@molbio.uzh.ch
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