Table of contents
From the editors
p157 | doi:10.1038/nrm2649
Research Highlights
Development: Deciphering the Wingless gradient | PDF (145 KB)
p159 | doi:10.1038/nrm2644
Cell cycle: Signalling to wait | PDF (171 KB)
p160 | doi:10.1038/nrm2643
Membrane dynamics: Clamping complexin | PDF (195 KB)
p160 | doi:10.1038/nrm2650
In brief
Telomeres | DNA-damage response | Ageing | microRNA | PDF (124 KB)
p161 | doi:10.1038/nrm2647
Cell signalling: NEMO keeps it straight | PDF (206 KB)
p162 | doi:10.1038/nrm2638
Technology Watch
Take your PICh | SUMO goes global | PDF (130 KB)
p162 | doi:10.1038/nrm2648
Mechanotransduction: Switch and stretch | PDF (151 KB)
p163 | doi:10.1038/nrm2642
Journal Club
Blebbing: motility research moves in a new direction | PDF (132 KB)
p164 | doi:10.1038/nrm2604
Cytoskeleton: The making of a filament | PDF (502 KB)
p164 | doi:10.1038/nrm2635
Reviews
Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system
Hellmut G. Augustin, Gou Young Koh, Gavin Thurston & Kari Alitalo
p165 | doi:10.1038/nrm2639
Tie receptors and their angiopoietin ligands have important functions during embryonic vessel assembly and maturation, and control adult vascular homeostasis. The structural characteristics and the spatio-temporal regulation of these receptors and ligands provide important insights into their functions.
Orchestrating nuclear envelope disassembly and reassembly during mitosis
Stephan Güttinger, Eva Laurell & Ulrike Kutay
p178 | doi:10.1038/nrm2641
The nuclear envelope is a dynamic structure that is disassembled and reassembled during 'open' mitosis in higher eukaryotes. These mitotic changes are subject to both spatial and temporal control mechanisms that are embedded in the more general regulatory network that directs cell division.
Article series: Chromatin dynamics
Epigenetic inheritance during the cell cycle
Aline V. Probst, Elaine Dunleavy & Geneviève Almouzni
p192 | doi:10.1038/nrm2640
Epigenetic inheritance concerns the mechanisms that ensure the transmission of epigenetic marks from mother to daughter cell. Chromatin modifications and nuclear organization are candidate epigenetic marks — whether they fulfil the criterion of heritability and what mechanisms ensure their propagation is an area of intensive research.
Article series: Stem cells
Epidermal homeostasis: a balancing act of stem cells in the skin
Cédric Blanpain & Elaine Fuchs
p207 | doi:10.1038/nrm2636
The proper establishment of the skin barrier during embryogenesis and its maintenance during adult homeostasis is crucial for survival. Interestingly, the molecular mechanisms that govern embryonic development of the epidermis are reused during adult life to regulate skin homeostasis.
ABC transporters: the power to change
Douglas C. Rees, Eric Johnson & Oded Lewinson
p218 | doi:10.1038/nrm2646
ATP-binding cassette (ABC) transporters are responsible for the ATP-powered translocation of many substrates across membranes. Structural similarities support a common mechanism by which ABC transporters, both importers and exporters, couple the binding and hydrolysis of ATP to substrate translocation.
Perspective
Opinion
Single proteins might have dual but related functions in intracellular and extracellular microenvironments
Derek C. Radisky, Melody Stallings-Mann, Yohei Hirai & Mina J. Bissell
p228 | doi:10.1038/nrm2633
Maintenance of organ homeostasis and control of appropriate responses to environmental alterations requires the coordination of cellular functions and tissue organization. This coordination could be achieved by proteins that can have distinct but linked functions on both sides of the plasma membrane.
Erratum: Mechanisms of regulated unconventional protein secretion
Walter Nickel & Catherine Rabouille
p234 | doi:10.1038/nrm2645
