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Research Highlights
Nature Reviews Molecular Cell Biology 10, 160–161 (1 March 2009) | doi:10.1038/nrm2650
Membrane dynamics: Clamping complexin
Abstract
The protein complexin interacts with the SNARE (soluble NSF-attachment protein receptor) complex and regulates neurotransmitter release. Two groups have analysed the molecular structure of complexin and conclude that its accessory helix acts as a fusion clamp (preventing fusion), whereas its amino-terminal domain acts as a fusion enhancer.
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