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Perspective
Nature Reviews Molecular Cell Biology 10, 228–234 (1 March 2009) | doi:10.1038/nrm2633
Single proteins might have dual but related functions in intracellular and extracellular microenvironments
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Abstract
The maintenance of organ homeostasis and the control of an appropriate response to environmental alterations require the intimate coordination of cellular functions and tissue organization. An important component of this coordination could be provided by proteins that can have distinct but linked functions on both sides of the plasma membrane. We present a model that proposes that unconventional secretion provides a mechanism through which single proteins can integrate complex tissue functions.
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