Perspectives
Nature Reviews Molecular Cell Biology 10, 228-234 (March 2009) | doi:10.1038/nrm2633
Opinion: Single proteins might have dual but related functions in intracellular and extracellular microenvironments
Derek C. Radisky1, Melody Stallings-Mann1, Yohei Hirai2 & Mina J. Bissell3 About the authors
Abstract
The maintenance of organ homeostasis and the control of an appropriate response to environmental alterations require the intimate coordination of cellular functions and tissue organization. An important component of this coordination could be provided by proteins that can have distinct but linked functions on both sides of the plasma membrane. We present a model that proposes that unconventional secretion provides a mechanism through which single proteins can integrate complex tissue functions.
Author affiliations
- Derek C. Radisky and Melody Stallings-Mann are at the Mayo Clinic Cancer Center, 4500 San Pablo Road, Jacksonville, Florida 32224, USA.
- Yohei Hirai is at the Department of Morphoregulation, Institute for Frontier Medical Sciences, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
- Mina J. Bissell is at the Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 977, Berkeley, California 94720, USA.
Correspondence to: Derek C. Radisky1 radisky.derek@mayo.edu
Published online 4 February 2009
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