Membrane trafficking: IFT proteins play a new game | PDF (146 KB)

p812 | doi:10.1038/nrm2811

DNA damage response: Keeping telomerase at bay | PDF (145 KB)

p813 | doi:10.1038/nrm2801

Microscopy: And then there was light | PDF (137 KB)

p814 | doi:10.1038/nrm2808

DNA replication: Cohesin on the fork | PDF (142 KB)

p814 | doi:10.1038/nrm2810

Plant cell biology: To die for | PDF (219 KB)

p815 | doi:10.1038/nrm2802

Cell migration: The benefit of being single | PDF (205 KB)

p816 | doi:10.1038/nrm2798

Circadian rhythms: Calibrating the clock | PDF (184 KB)

p816 | doi:10.1038/nrm2806

Fine-tuning of GPCR activity by receptor-interacting proteins

Stefanie L. Ritter & Randy A. Hall

p819 | doi:10.1038/nrm2803

G protein-coupled receptors (GPCRs) mediate physiological responses to various hormones, neurotransmitters, sensory stimuli and other ligands. The signalling and trafficking properties of GPCRs are often fine-tuned by receptor-interacting proteins that are differentially expressed in distinct cell types.

• Abstract
• Full Text
• PDF (474 KB)

Tissue remodelling through branching morphogenesis

Markus Affolter, Rolf Zeller & Emmanuel Caussinus

p831 | doi:10.1038/nrm2797

Branched structures are present at all levels of organization in living organisms. Recent studies suggest that cell competition and cell rearrangements might be conserved key features in branch formation that are controlled by local cell signalling events.

• Abstract
• Full Text
• PDF (656 KB)

Integrins: masters and slaves of endocytic transport

Patrick T. Caswell, Suryakiran Vadrevu & Jim C. Norman

p843 | doi:10.1038/nrm2799

How integrins are trafficked by endocytosis markedly affects their distribution and function. Recent studies examining the molecular mechanisms of integrin trafficking show that it affects the recycling of key signalling receptors to influence cellular processes such as cytokinesis, cell migration and tumour angiogenesis.

• Abstract
• Full Text
• PDF (628 KB)

Regulators of the cytoplasmic dynein motor

Julia R. Kardon & Ronald D. Vale

p854 | doi:10.1038/nrm2804

A single type of dynein motor carries out all minus end-directed microtubule transport in the cytoplasm. Several multifunctional adaptors, including dynactin, LIS1, NUDE and NUDEL, Bicaudal D and RZZ, couple dynein to its wide range of cargos and regulate its function.

• Abstract
• Full Text
• PDF (718 KB)

Exploring protein fitness landscapes by directed evolution

Philip A. Romero & Frances H. Arnold

p866 | doi:10.1038/nrm2805

Directed evolution optimizes protein function through successive generations of random mutation, artificial selection and screening. This design algorithm provides a reliable approach to engineering proteins with new and useful properties, and helps us to understand how natural evolution occurs.

• Abstract
• Full Text
• PDF (506 KB)