Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Research Highlights
Nature Reviews Molecular Cell Biology 10, 813 (1 December 2009) | doi:10.1038/nrm2801
DNA damage response: Keeping telomerase at bay
Abstract
The enzyme telomerase maintains chromosome integrity by synthesizing telomeres at chromosome ends. What prevents telomerase from adding telomeres to double-stranded DNA breaks (DSBs)? In Nature Cell Biology, Svetlana Makovets and Elizabeth Blackburn now report that DNA damage signalling induces phosphorylation of the telomerase inhibitor Pif1 (petite integration frequency 1).
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
