Abstract

Old and newly synthesized centrosomes have different microtubule nucleating abilities and they contribute to cell polarity when they migrate to opposite poles during cell division. The asymmetric localization of epigenetic marks and kinetochore proteins could lead to the differential recognition of sister chromatids and the biased segregation of DNA strands to daughter cells during cell division. We propose that this asymmetric localization is linked to biased chromatid segregation, which might also be related to the acquisition of distinct cell fates after mitosis.

Author affiliations

1. Shahragim Tajbakhsh is at the Stem Cells and Development Department of Developmental Biology, Institut Pasteur, CNRS URA 2578, 25 rue du Dr. Roux, 75724 Paris, Cedex 15, France.
2. Cayetano Gonzalez is at the Cell Division Laboratory, Institut de Recerca Biomedica, PCB. C/ Baldiri Reixac 10–12, 08028 Barcelona, Spain and the Institucio Catalana de Recerca i Estudis Avançats, Passeig Lluis Companys 23, 08010 Barcelona, Spain.
   Email: shaht@pasteur.fr; Email: gonzalez@irbbarcelona.org

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