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Cancer: looking outside the genome

Nature Reviews Molecular Cell Biology volume 1, pages 76–79 (2000)Cite this article

Abstract

The ‘gene-centric’ approach has produced a wealth of information about the origins and progression of cancer, and investigators seek a full compilation of altered gene expressions for tumour characterization and treatment. However, the cancer genome appears to be far more unstable than previously thought. It may therefore be prudent to augment gene-level approaches with supra-genomic strategies that circumvent the genomic variability of cancer cells.

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Figure 1: Diffusion constraints govern tumour growth.
Figure 2: Endothelial and tumour cells as targets.

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Acknowledgements

We thank G. Anderson, R. Kerbel and B. Vogelstein for reading the manuscript and for their comments. We thank C. Lamont for figure graphics.

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Authors and Affiliations

  1. Department of Surgery, and Departments of Cell Biology and Surgery, Laboratory of Surgical Research, Children's Hospital, Harvard Medical School, Boston, 02115, Massachusetts, USA

    Judah Folkman

  2. Department of Adult Oncology, and Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, 02115, Massachusetts, USA

    Philip Hahnfeldt & Lynn Hlatky

  3. Philip Hahnfeldt & Lynn Hlatky

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  1. Judah Folkman
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  2. Philip Hahnfeldt
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  3. Lynn Hlatky
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Folkman, J., Hahnfeldt, P. & Hlatky, L. Cancer: looking outside the genome. Nat Rev Mol Cell Biol 1, 76–79 (2000). https://doi.org/10.1038/35036100

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