Perspectives
Nature Reviews Molecular Cell Biology 1, 76-79 (October 2000) | doi:10.1038/35036100
Opinion: Cancer: looking outside the genome
Judah Folkman1, Philip Hahnfeldt2 & Lynn Hlatky2 About the authors
Top of page
Abstract
The 'gene-centric' approach has produced a wealth of information about the origins and progression of cancer, and investigators seek a full compilation of altered gene expressions for tumour characterization and treatment. However, the cancer genome appears to be far more unstable than previously thought. It may therefore be prudent to augment gene-level approaches with supra-genomic strategies that circumvent the genomic variability of cancer cells.
Author affiliations
-
Laboratory of Surgical Research, Department of Surgery, Children's Hospital, and Departments of Cell Biology and Surgery, Harvard Medical School, Boston, Massachusetts 02115, USA.
Email: foss@hub.tch.harvard.edu. -
Department of Adult Oncology, Dana-Farber Cancer Institute, and Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Email: Philip_Hahnfeldt@dfci.harvard.edu; Email: lynn_hlatky@dfci.harvard.edu
