Review
Nature Reviews Molecular Cell Biology 1, 22-30 (October 2000) | doi:10.1038/35036044
A tale of toroids in DNA metabolism
Manju M. Hingorani1 & Mike O'Donnell1,2 About the authors
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Abstract
A strikingly large number of the proteins involved in DNA metabolism adopt a toroidal ? or ring-shaped ? quaternary structure, even though they have completely unrelated functions. Given that these proteins all use DNA as a substrate, their convergence to one shape is probably not a coincidence. Ring-forming proteins may have been selected during evolution for advantages conferred by the toroidal shape on their interactions with DNA.
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Author affiliations
-
The Rockefeller University, 1230 York
Avenue, New York, New York 10021,
USA.
Email: manju@mod.rockefeller.edu -
The Howard Hughes Medical Institute,
1230 York Avenue, New York, New York 10021
, USA.
Email: odonnel@rockvax.rockefeller.edu
