NPG library
Below is a selection of recent Reviews, Perspectives, Research articles, News and Views and Research Highlights that have been published by Nature Publishing Group on the topic of ageing.
Reviews
Stressing the role of FoxO proteins in lifespan and disease
Armando van der Horst & Boudewijn M.T. Burgering
doi:10.1038/nrm2190
Nature Reviews Molecular Cell Biology 8, 440-450
Werner and Hutchinson�Gilford progeria syndromes: mechanistic basis of human progeroid diseases
Brian A. Kudlow, Brian K. Kennedy & Raymond J. Monnat, Jr
doi:10.1038/nrm2161
Nature Reviews Molecular Cell Biology 8, 394-404
Human laminopathies: nuclei gone genetically awry
Brian C. Capell & Francis S. Collins
doi:10.1038/nrg1906
Nature Reviews Genetics 7, 940-952
The quest for genetic determinants of human longevity: challenges and insights
Kaare Christensen, Thomas E. Johnson & James W. Vaupel
doi:10.1038/nrg1871
Nature Reviews Genetics 7, 436-448
Perspectives
Darwinian medicine: a case for cancer
Mel Greaves
doi:10.1038/nrc2071
Nature Reviews Cancer 7, 213-221
Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging
Elizabeth H Blackburn, Carol W Greider & Jack W Szostak
doi:10.1038/nm1006-1133
Nature Medicine 12, 1133-1138
How genetic analysis tests theories of animal aging
Siegfried Hekimi
doi:10.1038/ng1881
Nature Genetics 38, 985-991
Research articles
Telomere protection by mammalian Pot1 requires interaction with Tpp1
Dirk Hockemeyer, Wilhelm Palm, Tobias Else, Jan-Peter Daniels, Kaori K Takai, Jeffrey Z-S Ye, Catherine E Keegan, Titia de Lange & Gary D Hammer
doi:10.1038/nsmb1270
Nature Structural and Molecular Biology 14, 754-761
The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins
Patrick Ryan Potts & Hongtao Yu
doi:10.1038/nsmb1259
Nature Structural and Molecular Biology 14, 581-590
Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment
Zhenyu Ju, Hong Jiang, Maike Jaworski, Chozhavendan Rathinam, Anne Gompf, Christoph Klein, Andreas Trumpp & K Lenhard Rudolph
doi:10.1038/nm1578
Nature Medicine 13, 742-747
Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
Christopher J. Sarkisian, Blaine A. Keister, Douglas B. Stairs, Robert B. Boxer, Susan E. Moody & Lewis A. Chodosh
doi:10.1038/ncb1567
Nature Cell Biology 9, 493-505
p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM
Hoseok Song, Monica Hollstein & Yang Xu
doi:10.1038/ncb1571
Nature Cell Biology 9, 573-580
Mitochondrial point mutations do not limit the natural lifespan of mice
Marc Vermulst, Jason H Bielas, Gregory C Kujoth, Warren C Ladiges, Peter S Rabinovitch, Tomas A Prolla & Lawrence A Loeb
doi:10.1038/ng1988
Nature Genetics 39, 540-543
Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster
James Jiayuan Tong, Samuel E Schriner, David McCleary, Brian J Day & Douglas C Wallace
doi:10.1038/ng2004
Nature Genetics 39, 476-485
RPA-like proteins mediate yeast telomere function
Hua Gao, Rachel B Cervantes, Edward K Mandell, Joel H Otero & Victoria Lundblad
doi:10.1038/nsmb1205
Nature Structural and Molecular Biology 14, 208-214
Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models
C.Q. Scheckhuber, N. Erjavec, A. Tinazli, A. Hamann, T. Nystr�m & H.D. Osiewacz
doi:10.1038/ncb1524
Nature Cell Biology 9, 99-105
H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability
Jamy C. Peng & Gary H. Karpen
doi:10.1038/ncb1514
Nature Cell Biology 9, 25-35
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
Aaheli Roy Choudhury, Zhenyu Ju, Meta W Djojosubroto, Andrea Schienke, Andre Lechel, Sonja Schaetzlein, Hong Jiang, Anna Stepczynska, Chunfang Wang, Jan Buer, Han-Woong Lee, Thomas von Zglinicki, Arnold Ganser, Peter Schirmacher, Hiromitsu Nakauchi & K Lenhard Rudolph
doi:10.1038/ng1937
Nature Genetics 39, 99-105
Mitogenic signalling and the p16INK4a�Rb pathway cooperate to enforce irreversible cellular senescence
Akiko Takahashi, Naoko Ohtani, Kimi Yamakoshi, Shin-ichi Iida, Hidetoshi Tahara, Keiko Nakayama, Keiichi I. Nakayama, Toshinori Ide, Hideyuki Saya & Eiji Hara
doi:10.1038/ncb1491
Nature Cell Biology 8, 1291-1297
Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants
Raquel Moreno-Loshuertos, Rebeca Ac�n-P�rez, Patricio Fern�ndez-Silva, Nieves Movilla, Acisclo P�rez-Martos, Santiago Rodriguez de Cordoba, M Esther Gallardo & Jos� Antonio Enr�quez
doi:10.1038/ng1897
Nature Genetics 38, 1261-1268
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP
Armando van der Horst, Alida M.M. de Vries-Smits, Arjan B. Brenkman, Miranda H. van Triest, Niels van den Broek, Fr�d�ric Colland, Madelon M. Maurice & Boudewijn M.T. Burgering
doi:10.1038/ncb1469
Nature Cell Biology 8, 1064-1073
News and Views
Mitochondrial DNA mutations and aging: a case closed?
Konstantin Khrapko & Jan Vijg
doi:10.1038/ng0407-445
Nature Genetics 39, 445-446
Stressed marrow: FoxOs stem tumour growth
Paul J. Coffer & Boudewijn M. T. Burgering
doi:10.1038/ncb0307-251
Nature Cell Biology 9, 251-253
A common means to an end
Stuart J Haring & Marc S Wold
doi:10.1038/nsmb0307-176
Nature Structural and Molecular Biology 14, 176-177
Telomeres, p21 and the cancer-aging hypothesis
Jessica F Bell & Norman E Sharpless
doi:10.1038/ng0107-11
Nature Genetics 39, 11-12
Research Highlights
The power of arrest
Arianne Heinrichs
doi:10.1038/nrm2200
Nature Reviews Molecular Cell Biology 8, 514-515
Similar signs
Ekat Kritikou
doi:10.1038/nrm2171
Nature Reviews Molecular Cell Biology 8, 341
New syndrome reconciles theories of ageing
Patrick Goymer
doi:10.1038/nrg2050
Nature Reviews Genetics 8, 90
Balancing self-renewal and ageing
Ekat Kritikou
doi:10.1038/nrm2036
Nature Reviews Molecular Cell Biology 7, 708
Longevity mutations inhibit tumours
Patrick Goymer
doi:10.1038/nrg1972
Nature Reviews Genetics 7, 742-743
Perils of ageing
Asher Mullard
doi:10.1038/nrm2029
Nature Reviews Molecular Cell Biology 7, 706-707
Connected clues?
Arianne Heinrichs
doi:10.1038/nrm2015
Nature Reviews Molecular Cell Biology 7, 624
