T cells: the usual subsets

Chen Dong and Gustavo J. Martinez

Each individual T cell has a unique personality that is shaped by the environmental factors it encounters during its life history. Broadly speaking, however, T cells can be grouped into various subsets based on their effector functions and molecular phenotype. Distinct T cell subsets promote different types of immune response; for example, cytotoxic T cells kill infected or transformed cells and regulatory T cells dampen excessive inflammation. The ability to identify and specifically target individual T cell subsets is important for basic immunological research and is also likely to be essential for the development of new immunotherapies.

This Poster summarizes the key characteristics of the main T cell subsets that have been described to date. The Poster is freely available thanks to support from Abcam.