Myeloid-derived suppressor cells

Vincenzo Bronte and Dmitry Gabrilovich

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that are defined by their myeloid origin, immature state and ability to potently suppress T cell responses. They regulate immune responses and tissue repair in healthy individuals and the population rapidly expands during inflammation, infection and cancer. Several therapeutic strategies are now being developed to target MDSCs to promote antitumour immune responses or to inhibit immune responses in the setting of autoimmune disease or transplant rejection. This poster provides an overview of the development, activation and effects of MDSCs, an understanding of which is crucial for effective therapeutic targeting. This poster is freely available thanks to support from BioLegend.