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Haematopoietic stem cells (HSCs) are characterized by extensive self-renewal capacity and the ability to differentiate into multiple cell lineages of the immune system. Much current research is focused on understanding the nature of HSC niches and the molecular interactions between cells in these niches. The nature of the early stages of HSC development is also a hot topic in the HSC field.
This poster provides an overview of HSC niches, including details of the molecules that mediate interactions between HSCs, osteoblasts and CXCL12-expressing reticular cells in these niches. The differentiation pathways of HSC-derived cells of the immune system are also illustrated, including the lineage-instructive factors that mediate each developmental stage. The poster is freely available thanks to support from Abcam.
