T cell memory: Keeping energy levels up | PDF (145 KB)

p458 | doi:10.1038/nri2593

HIV: Selective pressure | PDF (160 KB)

p459 | doi:10.1038/nri2595

T cell memory: Live long with WNT | PDF (193 KB)

p460 | doi:10.1038/nri2594

T cell differentiation: Inhibiting T_H17 cells | PDF (413 KB)

p460 | doi:10.1038/nri2601

Antigen presentation: Basophils do it too | PDF (207 KB)

p462 | doi:10.1038/nri2592

T cell responses: A new starting point | PDF (300 KB)

p462 | doi:10.1038/nri2597

Antiviral immunity: TRIMming the response | PDF (190 KB)

p463 | doi:10.1038/nri2589

Evolution: A common solution to an age-old problem | PDF (379 KB)

p464 | doi:10.1038/nri2590

Signalling through C-type lectin receptors: shaping immune responses

Teunis B. H. Geijtenbeek & Sonja I. Gringhuis

p465 | doi:10.1038/nri2569

Here, Teunis Geijtenbeek and Sonja Gringhuis discuss the role of the signalling pathways induced by C-type lectin receptors in determining T helper cell lineage commitment and describe how these pathways can be exploited for the development of new vaccination strategies.

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New insights into the regulation of T cells by _c family cytokines

Yrina Rochman, Rosanne Spolski & Warren J. Leonard

p480 | doi:10.1038/nri2580

In this Review, the authors discuss the central roles of the common cytokine receptor -chain (_c) family of cytokines, as well as the related cytokine TSLP, in the homeostasis, proliferation and differentiation of various T cell subsets and describe how these cytokines could be exploited for therapeutic purposes.

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Cracking the BAFF code

Fabienne Mackay & Pascal Schneider

p491 | doi:10.1038/nri2572

Studies showing how BAFF and its closely related homologue APRIL activate their receptors and transmit growth and survival signals to B cells have shed new light on the association between BAFF and autoimmunity. This knowledge has prompted several clinical trials testing BAFF and APRIL antagonists for the treatment of autoimmune diseases and lymphomas.

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MHC class I antigen presentation: learning from viral evasion strategies

Ted H. Hansen & Marlene Bouvier

p503 | doi:10.1038/nri2575

To limit detection by host T cells, viruses have evolved numerous mechanisms to inhibit viral antigens being processed and presented by MHC class I molecules. As described here, studying these viral immune evasion strategies is proving useful for understanding MHC class I presentation and other cellular pathways.

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CD95, BIM and T cell homeostasis

Philippe Bouillet & Lorraine A. O'Reilly

p514 | doi:10.1038/nri2570

Cell death has a vital role in maintaining homeostasis in the T cell pool. However, the specific roles of BIM and CD95 in the contraction phase of T cell responses has been controversial. Recent studies show that BIM and CD95 have complementary roles in this process.

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