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Research Highlights
Nature Reviews Immunology 9, 391 (1 June 2009) | doi:10.1038/nri2576
Neuroimmunology: Basement membrane laminins guard the CNS
Abstract
The extravasation of myelin-specific CD4+ T cells from the blood into the central nervous system (CNS) is a crucial factor in the pathogenesis of multiple sclerosis. We know much about how leukocytes traverse the endothelial cell monolayer of post-capillary venules, but far less is known about how they cross the underlying basement membrane, which is the rate-limiting step in transmigration.
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