From the editors
p143 | doi:10.1038/nri2523
Table of contents
Research Highlights
T-cell memory: The road not taken | PDF (127 KB)
p145 | doi:10.1038/nri2514
Lymphocyte migration: 'Guided' tour of the brain | PDF (275 KB)
p146 | doi:10.1038/nri2509
Innate immunity: Unfolding antiviral defences | PDF (252 KB)
p146 | doi:10.1038/nri2516
Inflammation: Taking AIM in the cytoplasm | PDF (191 KB)
p147 | doi:10.1038/nri2511
Tissue-specific immunity: Balancing act | PDF (193 KB)
p148 | doi:10.1038/nri2518
Granulocyte development: Vitamin B3: a neutrophil supplement | PDF (223 KB)
p148 | doi:10.1038/nri2521
Tumour immunology: Multi-tasking by STAT3 | PDF (164 KB)
p149 | doi:10.1038/nri2517
Antigen presentation: Parasite hijacking | PDF (118 KB)
p150 | doi:10.1038/nri2512
Regulatory T cells: Suppression dissected | PDF (151 KB)
p150 | doi:10.1038/nri2513
In brief
Natural killer cells | Neuroimmunology | T-cell responses | PDF (143 KB)
p150 | doi:10.1038/nri2520
In brief
Haematopoiesis | T-cell responses | Cell migration | PDF (124 KB)
p151 | doi:10.1038/nri2519
Reviews
Article series: Tissue-specific immune responses
Migration, maintenance and recall of memory T cells in peripheral tissues
David L. Woodland & Jacob E. Kohlmeier
p153 | doi:10.1038/nri2496
Memory T cells in non-lymphoid tissues provide an important early line of defence against secondary pathogen infection. In this article, the mechanisms involved in the migration, maintenance and function of memory T cells at these peripheral sites are discussed.
Myeloid-derived suppressor cells as regulators of the immune system
Dmitry I. Gabrilovich & Srinivas Nagaraj
p162 | doi:10.1038/nri2506
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expands during cancer, inflammation and infection. Here, the authors discuss the mechanisms of MDSC expansion and suppression of T-cell function in vivo, and describe how these cells might be targeted for therapeutic purposes.
E and ID proteins branch out
Barbara L. Kee
p175 | doi:10.1038/nri2507
Haematopoiesis is driven by complex networks of transcriptional regulators. Among them are the E and inhibitor of DNA binding (ID) proteins, which have important roles in early B- and T-cell development, as well as emerging roles in haematopoietic stem cells and other lymphoid and myeloid lineages.
B-cell responses to vaccination at the extremes of age
Claire-Anne Siegrist & Richard Aspinall
p185 | doi:10.1038/nri2508
Infant and elderly humans and mice have a similar vulnerability to common pathogens as a result of the decreased quantity and persistence of antibody responses. This Review looks at the B-cell intrinsic factors and microenvironmental determinants in lymphoid tissue and bone marrow that limit protective B-cell responses in these age groups.
Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling
Sebastian Herzog, Michael Reth & Hassan Jumaa
p195 | doi:10.1038/nri2491
Signalling through the pre-B-cell receptor is an important checkpoint in B-cell development. But, what are the molecular mechanisms that regulate cell proliferation, immunoglobulin light chain gene recombination and cell differentiation downstream of this receptor?
Perspectives
Opinion
Affinity threshold for thymic selection through a T-cell receptor–co-receptor zipper
Ed Palmer & Dieter Naeher
p207 | doi:10.1038/nri2469
How the T-cell receptor translates ligand affinity to an appropriate cellular response has puzzled immunologists for decades. In this Opinion article, the authors propose a new model to explain this, which is based on the duration of receptor–ligand binding and on a 'zipper' mechanism that mediates receptor–co-receptor interactions.
Science and society
Maintaining protection against invasive bacteria with protein–polysaccharide conjugate vaccines
Andrew J. Pollard, Kirsten P. Perrett & Peter C. Beverley
p213 | doi:10.1038/nri2494
In the light of the introduction of conjugate vaccines against Haemophilus influenzae type B and group C meningococcal and pneumococcal diseases over the past two decades, this Science & Society article discusses the ways in which long-term protection against these encapsulated bacteria might best be maintained at a population level.
