Review

Nature Reviews Immunology 9, 162-174 (March 2009) | doi:10.1038/nri2506

Myeloid-derived suppressor cells as regulators of the immune system

Dmitry I. Gabrilovich1 & Srinivas Nagaraj1  About the authors

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Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expand during cancer, inflammation and infection, and that have a remarkable ability to suppress T-cell responses. These cells constitute a unique component of the immune system that regulates immune responses in healthy individuals and in the context of various diseases. In this Review, we discuss the origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit.

Author affiliations

  1. H. Lee Moffitt Cancer Center and Research Institute, and Department of Oncologic Sciences, University of South Florida, Tampa, Florida, 33612, USA.

Correspondence to: Dmitry I. Gabrilovich1 Email: dmitry.gabrilovich@moffitt.org