Table of contents
February 2009 Vol 9 No 2
From the editors
p71 | doi:10.1038/nri2492
Research Highlights
T-cell development: Stimulating company | PDF (190 KB)
p72 | doi:10.1038/nri2502
Dendritic cells: Coordinating motility and function | PDF (216 KB)
p73 | doi:10.1038/nri2493
In brief
T-cell development | Autoimmunity | T-cell development | PDF (133 KB)
p73 | doi:10.1038/nri2504
T-cell responses: Two for the price of one | PDF (161 KB)
p74 | doi:10.1038/nri2495
T-cell responses: Brainstorm by CD4+ T cells | PDF (205 KB)
p75 | doi:10.1038/nri2497
Lymphocyte migration: Getting to the site of action | PDF (198 KB)
p75 | doi:10.1038/nri2501
T-cell development: CD40–CD40L crosstalk in TH17-cell differentiation | PDF (151 KB)
p76 | doi:10.1038/nri2499
Dendritic cells: Tailoring T-helper-cell responses | PDF (126 KB)
p76 | doi:10.1038/nri2500
Natural killer cells: NK cells remember | PDF (146 KB)
p77 | doi:10.1038/nri2498
B cells: Living with the enemy! | PDF (202 KB)
p78 | doi:10.1038/nri2503
Vaccine Watch
RSV vaccine failure explained | Hope for T-cell-based HIV-1 vaccine | PDF (127 KB)
p78 | doi:10.1038/nri2505
Foreword
Decision making during the conception and career of CD4+ T cells
p81 | doi:10.1038/nri2490
Focus on: CD4+ T-cell diversity
Progress
Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?
Jochen Huehn, Julia K. Polansky & Alf Hamann
p83 | doi:10.1038/nri2474
Regulatory T (TReg) cells are crucial for immune homeostasis, and manipulation of their suppressive functions is a possible avenue for immunotherapy. Here, the authors discuss recent advances in our understanding of how the expression of forkhead box P3 (FOXP3), a TReg-cell-specifying transcription factor, is controlled at the molecular level.
Reviews
Epigenetic control of T-helper-cell differentiation
Christopher B. Wilson, Emily Rowell & Masayuki Sekimata
p91 | doi:10.1038/nri2487
Numerous lineage-specific transcription factors have been linked with T-helper-cell subset specification. But, as discussed here, epigenetic modifications at the gene regulatory elements where these factors bind can also contribute to the regulation of T-helper-cell differentiation and function.
RUNX proteins in transcription factor networks that regulate T-cell lineage choice
Amélie Collins, Dan R. Littman & Ichiro Taniuchi
p106 | doi:10.1038/nri2489
In this Review, the authors discuss how RUNX (runt-related transcription factor) proteins and other key transcription factors work together to direct T-cell lineage choice and CD4+ T-cell differentiation.
The different faces of Notch in T-helper-cell differentiation
Derk Amsen, Andrey Antov & Richard A. Flavell
p116 | doi:10.1038/nri2488
Recent research indicates that the Notch signalling pathway is important for directing T helper (TH)-cell differentiation. In this Review, the authors discuss contrasting results showing that Notch can have a role in both TH1- and TH2-cell differentiation, and highlight how this information might help to better understand the pathology of T-cell-mediated diseases.
GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation
I-Cheng Ho, Tzong-Shyuan Tai & Sung-Yun Pai
p125 | doi:10.1038/nri2476
The transcription factor GATA-binding protein 3 (GATA3) is best known as a master regulator of T-helper-2-cell differentiation. However, as part of a network of other transcription factors, GATA3 is also important in determining cell fate at earlier stages of haematopoiesis and lymphoid-cell development.
Perspective
Opinion
Regulation of T-helper-cell lineage development by osteopontin: the inside story
Harvey Cantor & Mari L. Shinohara
p137 | doi:10.1038/nri2460
Here, Harvey Cantor and Mari Shinohara propose that the secreted and intracellular isoforms of osteopontin differentially regulate the development of distinct T-helper-cell subsets and, consequently, adaptive immune responses to foreign and self antigens.
