Current Issue
From the editors
p817 | doi:10.1038/nri2677
Research Highlights
Mucosal immunology: Homing in on the friendliest of bacteria | PDF (199 KB)
p818 | doi:10.1038/nri2679
Innate immunity: HMGB proteins: universal sensors for nucleic acids | PDF (158 KB)
p819 | doi:10.1038/nri2676
In brief
HIV | Cytokines | Regulatory T cells | PDF (128 KB)
p819 | doi:10.1038/nri2683
Immune synapses: TCR–CD3 recycling to the synapse | PDF (171 KB)
p820 | doi:10.1038/nri2680
Natural killer T cells: Switching on human NKT cells | PDF (154 KB)
p820 | doi:10.1038/nri2681
In brief
Innate immunity | Transplantation | Tolerance | PDF (120 KB)
p820 | doi:10.1038/nri2684
Innate immunity: Coated for destruction in new defence strategy | PDF (206 KB)
p821 | doi:10.1038/nri2672
Macrophages: Self-renewing macrophages | PDF (233 KB)
p822 | doi:10.1038/nri2678
Tumour immunology: Inflammatory transformation | PDF (179 KB)
p822 | doi:10.1038/nri2682
Reviews
Naive T cell homeostasis: from awareness of space to a sense of place
Kensuke Takada & Stephen C. Jameson
p823 | doi:10.1038/nri2657
This Review describes our current understanding of how the 'space' for the peripheral naive T cell pool is influenced by competition for homeostatic signals and how the 'place' at which the T cells encounter these signals can influence their physical and functional maintenance.
Antigen presentation in the thymus for positive selection and central tolerance induction
Ludger Klein, Maria Hinterberger, Gerald Wirnsberger & Bruno Kyewski
p833 | doi:10.1038/nri2669
Recognition of self-peptide–MHC complexes in the thymus is necessary for thymocyte survival, but can also result in cell death. Here, the authors provide a unique insight into this apparent paradox, describing how the repertoire of self-peptide–MHC complexes that support T cell selection is shaped.
Dysregulation of germinal centres in autoimmune disease
Carola G. Vinuesa, Iñaki Sanz & Matthew C. Cook
p845 | doi:10.1038/nri2637
Germinal centres are hubs for the generation of long-lived high-affinity antibodies that are necessary for adaptive immunity, but they can also be the source of pathogenic autoantibodies. Here, the authors explore how dysregulation of germinal centres might contribute to autoimmune disease.
Article series: Tissue-specific immune responses
Tissue-mediated control of immunopathology in coeliac disease
Bana Jabri & Ludvig M. Sollid
p858 | doi:10.1038/nri2670
Coeliac disease results from an inappropriate response to dietary gluten. In this Review, the authors describe the ways in which intestinal tissue cells contribute to the inflammatory environment that leads to the induction of a tissue-destructive, gluten-specific T cell response.
Endolysosomal proteases and their inhibitors in immunity
Phillip I. Bird, Joseph A. Trapani & José A. Villadangos
p871 | doi:10.1038/nri2671
This Review discusses the recent studies revealing new roles for endolysosomal proteases in immune cells, as well as their well known involvement in antigen presentation. These include crucial activities in innate immunity, regulation of cell death and control of pathogen invasion.
Perspectives
Opinion
Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective
Casey T. Weaver & Robin D. Hatton
p883 | doi:10.1038/nri2660
These authors propose that the T helper 17 cell and induced regulatory T cell lineages were the first T cells of the adaptive immune system to evolve in vertebrates as a means to counter-regulate immune responses in the gut to foster a large, diverse commensal microbiota for the benefit of the host.
