Current Issue
From the editors
p749 | doi:10.1038/nri2664
Research Highlights
T cell development: Seeing self in a positive light | PDF (125 KB)
p751 | doi:10.1038/nri2661
Mast cells: Delivery of cytokine packages to the lymph nodes | PDF (151 KB)
p752 | doi:10.1038/nri2658
T cells: Crawling into the brain | PDF (176 KB)
p752 | doi:10.1038/nri2663
In brief
Innate immunity | Lymphoid organogenesis | T cell responses | PDF (117 KB)
p752 | doi:10.1038/nri2666
Immunotherapy: CpG–siRNA deals double blow to tumours | PDF (234 KB)
p753 | doi:10.1038/nri2665
Immune regulation: TReg cells offer a bespoke service | PDF (112 KB)
p754 | doi:10.1038/nri2659
In brief
Immune tolerance | Apoptosis | Tumour immunology | PDF (116 KB)
p754 | doi:10.1038/nri2667
Dendritic cells: Division of DC labour in the gut | PDF (107 KB)
p755 | doi:10.1038/nri2662
In the news
HIV vaccine results controversy | PDF (95 KB)
p755 | doi:10.1038/nri2668
Reviews
New insights into the differentiation and function of T follicular helper cells
Cecile King
p757 | doi:10.1038/nri2644
T follicular helper cells are strategically positioned in germinal centres and equipped to provide the signals necessary for antibody production by B cells. This Review describes the latest studies that explore their development and function and their relationship with other T helper cell subsets.
The follicular versus marginal zone B lymphocyte cell fate decision
Shiv Pillai & Annaiah Cariappa
p767 | doi:10.1038/nri2656
This Review proposes an integrated model for the development of follicular versus marginal zone B cells based on the coordination of B cell receptor signal strength with signals through Notch2 and the receptor for B cell-activating factor and signals that are involved in the migration to and retention of B cells in the marginal zone of the spleen.
Article series: Tissue-specific immune responses
Regulation of tissue homeostasis by NF-
B signalling: implications for inflammatory diseases
Manolis Pasparakis
p778 | doi:10.1038/nri2655
This Review focuses on the recent studies showing that inhibition of the nuclear factor-
B (NF-B) pathway in epithelial cells unexpectedly results in the spontaneous development of inflammatory conditions. These results imply a role for NF-B in these cells in controlling tissue homeostasis rather than promoting inflammation.
Analysing immune cell migration
Joost B. Beltman, Athanasius F. M. Marée & Rob J. de Boer
p789 | doi:10.1038/nri2638
Time-lapse video microscopy is an important experimental tool for examining the dynamic behaviour of immune cells in situ and involves quantitative analysis of cell migration and cell–cell interactions. Here, several commonly measured parameters and imaging artefacts are described and potential solutions to detect and correct these artefacts are proposed.
Intestinal mucosal barrier function in health and disease
Jerrold R. Turner
p799 | doi:10.1038/nri2653
Mucosal surfaces are lined by epithelial cells that establish a barrier between external environments and the internal milieu. Recent advances have uncovered mechanisms of barrier regulation by immune stimuli and, conversely, how mucosal immunity is regulated by barrier function.
Perspectives
Viewpoint
The functional plasticity of T cell subsets
Jeffrey A. Bluestone, Charles R. Mackay, John J. O'Shea & Brigitta Stockinger
p811 | doi:10.1038/nri2654
The recent re-evaluation of the concept that CD4+ T helper cell subsets are irreversibly differentiated lineages has become one of the most hotly debated issues in immunology. Here, four leaders in the field provide their thoughts on the complexities and controversies surrounding the functional plasticity of T cell subsets.
