Abstract

The seminal studies characterizing T follicular helper (T_FH) cells described a non-polarized CD4⁺ T cell population with a unique ability to home to B cell follicles and to induce antibody production by B cells. In the past few years, the study of T_FH cells has enjoyed a renaissance and there has been a surge of research activity aimed at understanding the function and differentiation of these important cells. This Review focuses on the current progress in T_FH cell biology and the important questions that remain unanswered. Particular attention is paid to recent studies that support the idea that T_FH cells are a separate T cell lineage and those that probe the relationship of T_FH cells to other T helper cell subsets.

Author affiliations

1. Department of Immunology, The Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia.
   Email: c.king@garvan.org.au

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