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Nature Reviews Immunology 8, 658–659 (1 September 2008) | doi:10.1038/nri2407

T cells: Sharing through a synapse

Lucy Bird

A close look at the behaviour of activated T cells in lymph nodes reveals that they engage with each other in dynamic clusters to share interleukin-2 (IL-2). To become activated, T cells engage with antigen-presenting cells (APCs), an interaction that is characterized by the formation of an immunological synapse.