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Research Highlights
Nature Reviews Immunology 8, 494 (1 July 2008) | doi:10.1038/nri2362
Gene regulation: Timing is everything
Abstract
The enormous diversity of the T-cell receptor (TCR) repertoire is generated by recombination of variable (V), diversity (D) and joining (J) gene segments. These segments must be joined in the correct linear orientation to generate a functional TCR, but they must also be rearranged sequentially in the correct order.
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