Table of contents
June 2008 Vol 8 No 6
From the editors
p399 | doi:10.1038/nri2350
Research Highlights
Lymphoid architecture: Restoration project | PDF (451 KB)
p400 | doi:10.1038/nri2344
Innate immunity: Linking hypoxia and NF-
B | PDF
(264 KB)
p401 | doi:10.1038/nri2341
In brief
Mucosal immunology | Immunogenetics | Mucosal immunology | PDF (99 KB)
p401 | doi:10.1038/nri2349
Autoimmunity: Type I interferon target revealed | PDF (210 KB)
p402 | doi:10.1038/nri2339
Mucosal vaccines: NKT cells help fight flu | PDF (270 KB)
p402 | doi:10.1038/nri2345
Regulatory T cells: Lending a hand to protective immunity | PDF (274 KB)
p402 | doi:10.1038/nri2352
In brief
Immune regulation | B-cell signalling | NKT cells | PDF (96 KB)
p403 | doi:10.1038/nri2354
T-cell signalling: ITAMs: quantity over quality | PDF (309 KB)
p404 | doi:10.1038/nri2351
Thymocyte development: Making a commitment | PDF (270 KB)
p404 | doi:10.1038/nri2353
Cytokines: Keep your partner close | PDF (371 KB)
p405 | doi:10.1038/nri2348
T-cell responses: DCs get KITted out | PDF (342 KB)
p406 | doi:10.1038/nri2346
In the news
Outmanoeuvering HIV | PDF (76 KB)
p406 | doi:10.1038/nri2347
Foreword
Focus on: Mucosal Immunology
Reviews
Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
David Artis
p411 | doi:10.1038/nri2316
It was thought that intestinal epithelial cells functioned solely as a barrier to the external environment, but as described here, these cells are now known to have an integral role in facilitating and controlling crosstalk between commensal bacteria and the immune system.
The regulation of IgA class switching
Andrea Cerutti
p421 | doi:10.1038/nri2322
IgA is the most abundant antibody class and provides a first line of defence at mucosal surfaces. Class switching to IgA occurs through both T-cell-dependent and T-cell-independent pathways, and recent studies reveal a role for commensal bacteria in intestinal IgA responses.
Dendritic cells in intestinal immune regulation
Janine L. Coombes & Fiona Powrie
p435 | doi:10.1038/nri2335
A delicate balance between tolerance to commensal bacteria and immunity to pathogens occurs in the intestine. Intestinal dendritic cells have a central role in maintaining this balance and, as described here, some of the molecular pathways involved have recently been resolved.
Setting the stage: host invasion by HIV
Florian Hladik & M. Juliana McElrath
p447 | doi:10.1038/nri2302
Infection by HIV requires the virus to breach the mucosal barrier to gain access to the immune cells that it infects. But what are the immediate events that follow HIV exposure at genital mucosal sites and what are the key cells that facilitate HIV invasion?
The genetics and immunopathogenesis of inflammatory bowel disease
Judy H. Cho
p458 | doi:10.1038/nri2340
Great progress has been made recently in the identification of genes or genetic loci that are associated with inflammatory bowel diseases. This knowledge is now providing insight into the pathogenesis of these diseases, highlighting roles for genes involved in bacterial sensing and cytokine signalling.
Reviews
Inhibitory B7-family molecules in the tumour microenvironment
Weiping Zou & Lieping Chen
p467 | doi:10.1038/nri2326
This Review describes how the expression of inhibitory members of the B7 family, particularly B7-H1 and B7-H4, by cancer cells, stromal cells and haematopoietic cells in the tumour microenvironment is regulated and acts to inhibit T-cell immunity, as well as the therapeutic implications.
Perspective
Opinion
Immunomodulatory mast cells: negative, as well as positive, regulators of immunity
Stephen J. Galli, Michele Grimbaldeston & Mindy Tsai
p478 | doi:10.1038/nri2327
In this Opinion article, Stephen Galli and colleagues discuss the recent evidence that mast cells can have negative, as well as positive, immunomodulatory functions, and suggest that mast cells might have distinct roles at different phases of an immune response.
Correspondence
Correspondence: B-cell-derived interleukin-10 in autoimmune disease: regulating the regulators
Aja Rieger & Amit Bar-Or
p486 | doi:10.1038/nri2315-c1
Corrigendum: T-cell quality in memory and protection: implications for vaccine design
Robert A. Seder, Patricia A. Darrah & Mario Roederer
p486 | doi:10.1038/nri2355
