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Research Highlights
Nature Reviews Immunology 8, 401 (1 June 2008) | doi:10.1038/nri2341
Innate immunity: Linking hypoxia and NF-|[kappa]|B
Abstract
The hypoxic response is crucial for tissue homeostasis and cell survival in low oxygen environments, and is essential for the normal function of innate immune cells in oxygen-deprived tissues. It has been established that innate immunity and the hypoxic response are linked at the molecular level, but the exact nature of this link was not previously known.
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