Review
Nature Reviews Immunology 8, 327-336 (May 2008) | doi:10.1038/nri2303
Immunobiology of the TAM receptors
Greg Lemke1 & Carla V. Rothlin1 About the authors
Abstract
Recent studies have revealed that the TAM receptor protein tyrosine kinases — TYRO3, AXL and MER — have pivotal roles in innate immunity. They inhibit inflammation in dendritic cells and macrophages, promote the phagocytosis of apoptotic cells and membranous organelles, and stimulate the maturation of natural killer cells. Each of these phenomena may depend on a cooperative interaction between TAM receptor and cytokine receptor signalling systems. Although its importance was previously unrecognized, TAM signalling promises to have an increasingly prominent role in studies of innate immune regulation.
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Author affiliations
- Molecular Neurobiology Laboratory, The Salk Institute, 10010 N. Torrey Pines Road, La Jolla, California 92037, USA
Correspondence to: Greg Lemke1 Email: lemke@salk.edu
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