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The TAM receptors — TYRO3, AXL and MER — are emerging as important regulators of innate immune responses. Here, the authors describe their roles in inhibiting inflammation driven by antigen-presenting cells, in promoting phagocytosis of apoptotic cells and in stimulating maturation of natural killer cells.
The study of T helper 17 (TH17) cells is one of the fastest-moving fields in immunology. Here, Chen Dong discusses our current understanding of this TH-cell lineage and examines some of the issues that remain to be resolved in this field.
Episodes of acute inflammation must be resolved to avoid tissue damage and chronic disease. Three families of lipid mediators — lipoxins, resolvins and protectins — actively promote the resolution of inflammation through multiple mechanisms, as discussed in this Review.
In this Review, Reinhold Förster and colleagues highlight recent advances in the understanding of how CC-chemokine receptor 7 (CCR7) and its two ligands, CCL19 and CCL21, contribute to both immunity and tolerance.
In this Review, Jenny Ting and colleagues discuss the role of the NLR (nucleotide-binding domain, leucine-rich repeat containing) family proteins in various forms of cell death, including two newly recognized types of cell death — pyroptosis and pyronecrosis.
Recent studies of T-cell leukaemia have provided insight into the molecular mechanisms responsible for the induction and progression of this disease. As discussed here, many of the genes that are dysregulated in T-cell leukaemia are known to be involved in T-cell development.
Accumulating evidence suggests that B cells can regulate immune responses. Here, the authors present a model to explain how B cells may regulate autoimmune pathology by secreting interleukin-10 in response to Toll-like receptor triggering and thereby mediate immune suppression.
