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Research Highlights
Nature Reviews Immunology 8, 166–167 (1 March 2008) | doi:10.1038/nri2283
Allergy and Asthma: What 'drives' IL-4 versus IL-13 signalling?
Abstract
Interleukin-4 (IL-4) and IL-13 are crucially involved in the development of allergic responses through their induction of T helper 2 (TH2) cells and promotion of IgE production. Both of these cytokines use the common γ-chain (γc)-related IL-4 receptor α-chain (IL-4Rα) to signal through three cytokine–receptor combinations: IL-4 signals through the type I receptor IL-4Rα–γc, and both IL-4 and IL-13 can signal through the type II receptor IL-4Rα–IL-13Rα1.
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