FIGURE 1 | Susceptibility genes for asthma and asthma-related traits.

From the following article:

Discovering susceptibility genes for asthma and allergy

Donata Vercelli

Nature Reviews Immunology 8, 169-182 (March 2008)


Discovering susceptibility genes for asthma and allergy

Summary of the genes that were found to be associated with asthma and/or asthma-related phenotypes in at least five independent reports of candidate-gene association or positional-cloning studies (these are underlined). Genes were identified by searching the public databases using the keyword 'association' together with each of the following terms: asthma, bronchial hyper-responsiveness, atopic dermatitis or IgE. Genes are ordered by their chromosomal location. Selected gene variants commonly associated with relevant phenotypes are shown. The information is updated to December 2007. References for studies published before 2006 are listed in Ref. 4. The references for the studies published in 2006 and 2007 are provided as Supplementary information S1 (table). ACE, angiotensin I converting enzyme 1 (also known as peptidyl-dipeptidase A); ADAM33, a disintegrin and metalloproteinase domain 33; ADRB2, beta2 adrenergic receptor; CC16, Clara cell-specific 16 kD protein (also known as SCGB1A1); CCL11, CC-chemokine ligand 11 (also known as eotaxin-1); CCL5, CC-chemokine ligand 5 (also known as RANTES); CD14, monocyte differentiation antigen 14; CMA1, chymase 1, mast cell; CTLA4, cytytoxic T-lymphocyte antigen 4; FCERIB, high-affinity Fc receptor for IgE beta-chain; FLG, filaggrin; GPRA, G-protein-coupled receptor for asthma susceptibility (also known as NPSR1, and GPRA154); GSTM1, glutathione S-transferase M1; GSTP1, glutathione S-transferase P1; GSTT1: glutathione S-transferase T1; HAVCR1, hepatitis A virus cellular receptor 1 (also known as TIM1); IL, interleukin; IL4R, interleukin-4 receptor (alpha-chain); LTA, lymphotoxin-alpha (also known as TNFbeta); LTC4S, leukotriene C4 synthase; NAT2, N-acetyltransferase 2; NOS1, nitric oxide synthase 1 (neuronal); SPINK5, serine protease inhibitor, Kazal-type, 5; STAT6, signal transducer and activator of transcription 6; TBXA2R, thromboxane A2 receptor; TGFB1, transforming growth factor-beta1; TNF, tumour necrosis factor.

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