Table of contents
February 2008 Vol 8 No 2
From the editors
p87 | doi:10.1038/nri2267
Research Highlights
T-cell activation: Where the action's at | PDF (230 KB)
p88 | doi:10.1038/nri2268
Tumour immunology: TGF
betrays immunity for tumorigenesis | PDF
(204 KB)
p89 | doi:10.1038/nri2263
In the news
HIV: The ultimate hijacker | PDF (118 KB)
p89 | doi:10.1038/nri2266
Innate immunity: NF-
B is not alone | PDF
(204 KB)
p90 | doi:10.1038/nri2259
Tumour immunotherapy: Little pig, little pig, let me come in | PDF (316 KB)
p90 | doi:10.1038/nri2265
In brief
B-cell responses | Inflammation | T-cell activation | PDF (90 KB)
p90 | doi:10.1038/nri2269
In brief
Inflammation | Mucosal immunology | Cytokines | PDF (142 KB)
p91 | doi:10.1038/nri2270
Phagocytosis: Autophagy lends a hand | PDF (381 KB)
p92 | doi:10.1038/nri2258
Thymocyte development: E proteins: manning the checkpoints | PDF (120 KB)
p92 | doi:10.1038/nri2261
Innate immunity: TAMing inflammation | PDF (344 KB)
p93 | doi:10.1038/nri2255
Dendritic cells: New DCs found deep in the skin | PDF (325 KB)
p94 | doi:10.1038/nri2256
Reviews
Evolving views on the genealogy of B cells
Robert S. Welner, Rosana Pelayo & Paul W. Kincade
p95 | doi:10.1038/nri2234
Views about the differentiation pathways of haematopoietic-cell lineages are evolving. No longer viewed as a series of binary fate decisions, evidence is emerging for the divergence, convergence and reversibility of haematopoiesis, as described here for B-cell development.
Shaping and reshaping CD8+ T-cell memory
John T. Harty & Vladimir P. Badovinac
p107 | doi:10.1038/nri2251
Here, John Harty and Vladimir Badovinac describe the factors that control the generation of memory CD8+ T cells, discuss how these factors can characterize this response and highlight how the manipulation of these factors could reshape CD8+ T-cell memory.
Micromanagement of the immune system by microRNAs
Harvey F. Lodish, Beiyan Zhou, Gwen Liu & Chang-Zheng Chen
p120 | doi:10.1038/nri2252
In this article, the authors provide a description of microRNA production and function, and discuss what is currently known about the role of microRNAs in the development and function of immune cells and in host–virus interactions.
Phagocytosis and comparative innate immunity: learning on the fly
Lynda M. Stuart & R. Alan Ezekowitz
p131 | doi:10.1038/nri2240
Studies in Drosophila melanogaster are proving fruitful for our understanding of phagocytosis in development, tissue homeostasis and host defence. In this Review, parallels are drawn between phagocytosis in flies and mammals, providing insight into its complexity and the evolutionary origins of immunity.
Regulation of immunological homeostasis in the respiratory tract
Patrick G. Holt, Deborah H. Strickland, Matthew E. Wikström & Frode L. Jahnsen
p142 | doi:10.1038/nri2236
The immune system has evolved specific mechanisms to deal with the unique problems encountered in the specialized microenvironment of the lung. This Review discusses the key mechanisms through which the local immune system maintains immunological homeostasis in the lung while preserving the integrity of the gas-exchange surfaces.
Perspective
Opinion
The reverse stop-signal model for CTLA4 function
Christopher E. Rudd
p153 | doi:10.1038/nri2253
Several models have been proposed to explain how cytotoxic T-lymphocyte antigen 4 (CLTA4) regulates T-cell activation but no model fully accounts for its overall function. Here, Christopher Rudd presents a new reverse stop-signal model, which can potentially explain multiple aspects of CTLA4 function.
Erratum: Creating immune privilege: active local suppression that benefits friends, but protects foes
Andrew L. Mellor & David H. Munn
p160 | doi:10.1038/nri2264