Table of contents
From the editors
p903 | doi:10.1038/nri2464
Research Highlights
Innate immunity: Seeing mTOR in a new light | PDF (168 KB)
p904 | doi:10.1038/nri2457
T-cell memory: Growing with experience | PDF (156 KB)
p905 | doi:10.1038/nri2463
In brief
Signalling | Immunotherapy | Regulatory T cells | PDF (132 KB)
p905 | doi:10.1038/nri2468
T cells: The flexibility of T-cell fates | PDF (165 KB)
p906 | doi:10.1038/nri2453
In the news
Pimp my ride | PDF (103 KB)
p906 | doi:10.1038/nri2462
Immunotherapy: Designer siRNA | PDF (135 KB)
p906 | doi:10.1038/nri2465
Thymocyte development: New roles for TRPM7 | PDF (125 KB)
p907 | doi:10.1038/nri2467
Viral immunity: Persistent viruses help opportunists | PDF (228 KB)
p908 | doi:10.1038/nri2452
Thymocyte development: Negative selection in the cortex | PDF (617 KB)
p908 | doi:10.1038/nri2459
Mucosal immunology: It starts with a NOD | PDF (200 KB)
p909 | doi:10.1038/nri2461
Allergy: Bee-keepers hold clues for T-cell tolerance | PDF (268 KB)
p910 | doi:10.1038/nri2466
In brief
Asthma and allergy | B cells | Inflammation | PDF (132 KB)
p910 | doi:10.1038/nri2469
Reviews
Viral evasion and subversion of pattern-recognition receptor signalling
Andrew G. Bowie & Leonie Unterholzner
p911 | doi:10.1038/nri2436
This Review highlights how understanding the mechanisms by which viruses evade and subvert host signalling by pattern-recognition receptors has provided insights into the function of these signalling pathways, the host proteins that are involved and ways in which the pathways might be manipulated therapeutically.
Nutrient sensing and inflammation in metabolic diseases
Gökhan S. Hotamisligil & Ebru Erbay
p923 | doi:10.1038/nri2449
This Review discusses how immune and inflammatory pathways are integrated with those that sense and manage nutrients, dysfunction of which underlies many chronic metabolic diseases, such as type 2 diabetes and atherosclerosis.
Article series: Tissue-specific immune responses
Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells
Miriam Merad, Florent Ginhoux & Matthew Collin
p935 | doi:10.1038/nri2455
Our understanding of the origin, phenotype and function of epidermal Langerhans cells and langerin-expressing dendritic cells has expanded in recent years, details of which, as well as the challenges that remain, are discussed in this Review.
Transcriptional regulation by AIRE: molecular mechanisms of central tolerance
Pärt Peterson, Tõnis Org & Ana Rebane
p948 | doi:10.1038/nri2450
This Review focuses on the structural domains of the autoimmune regulator (AIRE) protein, its nuclear localization, and its role in histone binding and transcriptional elongation, which help to explain the crucial involvement of AIRE in the negative selection of T cells in the thymus.
Exploring the full spectrum of macrophage activation
David M. Mosser & Justin P. Edwards
p958 | doi:10.1038/nri2448
By proposing new criteria by which macrophage populations can be classified based on functions that are involved in maintaining homeostasis, this Review provides a framework to further elucidate the functions of these cells and their role in disease.
Perspective
Science and society
Immunotherapy of autoimmunity and cancer: the penalty for success
Rachel R. Caspi
p970 | doi:10.1038/nri2438
Immunotherapy for cancer sometimes has autoimmune complications, and immunotherapy for autoimmunity can compromise microbial defence and immunosurveillance. In this article, Rachel Caspi explores the potential penalties of successful immunotherapeutic approaches and highlights the need for more specific modalities.
